Endocrine Abstracts

Introduction: In 7–20% of cases, Cushing’s disease is due to ACTH-producing macroadenoma. Aim of the study was to present our observations concerning etiologic, clinical, and therapeutic diversity of Cushing’s disease in patients with macrocorticotropinomas.Material and methods: Retrospective analysis of medical records of nine patients (5F; 4M) hospitalized in 2002–2015.Results: Four of the patients (2F; 2M) we...

Background: Meningitis coexisting with pituitary macroadenoma is rarely observed. It occurs either as a primary meningitis (primary tumor manifestation), or as a secondary meningitis (after neurosurgery or reduction of the volume of the tumor which has destroyed the sellar floor or the skull base).Objective: Case reports of two patients with the concomitance of secondary meningitis and pituitary macroadenoma.Case 1: A 36-year-old m...

The factors influencing the final outcomes of 131I therapy are indefinitely known, besides its practical use since more than 60 years. One of the considered factors affecting the results of 131I therapy is iodine metabolism.Aim: The aim of the study was the evaluation of the iodine uptake and the effective half-life of 131I influence on the result of radioactive iodine therapy in patients treated due to Graves’ hyper...

Introduction: WHO classification of endocrine tumors defines pheochromocytoma as a tumor arising from chromaffin cells in the adrenal medulla. Almost all pheochromocytomas produce catecholamines. An annual incidence of this tumor in the general population is estimated at 3–8 cases/million/year. 40–50% of patients with pheochromocytoma are characterized by sustained hypertension, a similar percentage – only by paroxysmal hypertension and up to 10% are normotensiv...

Introduction: ACTH-secreting macroadenomas account for about 4–10% of Cushing’s disease and are often resistant to surgical treatment and radiotherapy. The aim of the study was to present diagnostic and therapeutic difficulties in a case of cyclic recurrent ACTH-dependent Cushing’s syndrome due to atypical pituitary adenoma.Case report: 50-year-old man with visceral obesity was referred to hospital because of poor control of diabetes and h...

Introduction: Horner’s syndrome represents a clinical symptom that may result from a variety of lesions both in the central and peripheral nervous system. It is a combination of ipsilateral ptosis, pupillary miosis and anisocoria, enophthalmos and facial anhydrosis induced by disruption of the sympathetic innervation of the eye anywhere along its three-neuron trail. Tumors are the most frequent causes of Horner’s syndrome.Aim: Aim of the study ...

Introduction: Increased production of vasopressin plays a key role in the development of fluid retention and hyponatremia in patients with decompensated heart failure. Antidiuretic hormone deficiency in the course of diabetes insipidus leads to the loss of water, dehydration and hypernatremia. The aim of the study was to present difficulties in successful treatment of hyponatremia in a patient with cardiomyopathy and heart failure, receiving desmopressin because of postoperati...

Introduction: Bilateral adrenalectomy (BA) is rarely applied as a therapeutic procedure. It serves as a life-saving treatment in patients with persistent Cushing’s disease after an ineffective pituitary surgery or in ectopic ACTH production. Other indications for BA are: bilateral adrenocortical adenomas, congenital adrenal hyperplasia and bilateral phaeochromocytoma in patients with hereditary paraganglioma-phaeochromocytoma (PPS/PGL) syndromes. It is also a procedure of...

Introduction: Hyponatremia occurs in 33–69% of women with postpartum pituitary necrosis. The aim of the study was to present a patient in whom recurrent hyponatremia was one of the dominant symptoms of postpartum anterior pituitary hormones deficiency.A case report: 55-year-old woman with a diagnosis of Sheehan syndrome established 19 years after the last labor complicated by massive bleeding due to uterine atonia. The first symptoms of pituitary in...

Aim: The aim of the study was the evaluation of the TSHRAb level changes and the comparison with thyroid function in patients with Graves’ disease treated with 131I 10 years ago.Material and methods: The study has been conducted in 67 patients (57 women, 10 men) aged 27–72 y (mean 48 years) with Graves’ disease.All patients were treated with 131I due to hyperthyroidism confirmed by fT3, fT4 and ...